V-9302 Chemical Properties

Boiling point:

688.7±55.0 °C(Predicted)

Density 

1.179±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:85.0(Max Conc. mg/mL);157.79(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);46.41(Max Conc. mM)
Ethanol:60.0(Max Conc. mg/mL);111.38(Max Conc. mM)
Water:50.5(Max Conc. mg/mL);93.75(Max Conc. mM)

form 

A crystalline solid

pka

2.08±0.10(Predicted)

color 

White to yellow

V-9302 Usage And Synthesis

Biological Activity

V-9302 is a selective competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity. V-9302 caused reduced cellular viability and increased cell death in a panel of cancer cell lines and reduced tumor cell growth in both HCT-116 and HT29 (Fig. 5f) xenograft models.