endo-BCN-PEG3-Biotin
endo-BCN-PEG3-Biotin Basic information
- Product Name:
- endo-BCN-PEG3-Biotin
- Synonyms:
-
- endo-BCN-PEG3-Biotin
- BCN-endo-PEG3-Biotin
- 5,8,11-Trioxa-2,14-diazanonadecanoic acid, 19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
- (1R,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-5,8,11-trioxa-2,14-diazanonadecanoate
- CAS:
- 1263166-92-2
- MF:
- C29H46N4O7S
- MW:
- 594.76
- Product Categories:
-
- peg
- ADC LINKER
- Mol File:
- 1263166-92-2.mol
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endo-BCN-PEG3-Biotin Chemical Properties
- Boiling point:
- 847.5±65.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 12.05±0.46(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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endo-BCN-PEG3-Biotin Usage And Synthesis
Uses
BCN-PEG3-Biotin is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-Biotin is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
Non-cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
endo-BCN-PEG3-BiotinSupplier
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
Zhengzhou Acme Chemical Co., Ltd.
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- 0371-037163312495,13303845143 13303845143
- 3001379618@qq.com
Alfa Chemistry
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- +1-5166625404;
- Info@alfa-chemistry.com
Nanchang Tianzhen Biotechnology Co., Ltd
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- 13758194781 13173652190
- 522013271@qq.com
Shanghai Haohong Pharmaceutical Co., Ltd.
- Tel
- 400-8210725 4008210725
- malulu@leyan.com