GR 113808 Chemical Properties

Boiling point:

572.3±53.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 44 mg/mL, soluble

form 

solid

pka

11.22±0.40(Predicted)

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GR 113808 Usage And Synthesis

Uses

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca²⁺) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Definition

ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.

Biological Activity

Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.

Biochem/physiol Actions

GR 113808 is a 5-HT4 serotonin receptor antagonist.

storage

Store at RT

GR 113808(144625-51-4)Related Product Information

• [1-(2-aminoethyl)-4-piperidinyl]methanol
• GR 113808
• [3H]GR-113808