GR 113808

Product Name: GR 113808
CAS No.: 144625-51-4
Chemical Name: GR 113808
Synonyms: GR 113808;GR113808, selective 5-HT4 antagonist;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
CBNumber: CB8494704
Molecular Formula: C19H27N3O4S
Formula Weight: 393.5
MOL File: 144625-51-4.mol

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GR 113808 Property

Boiling point:: 572.3±53.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 44 mg/mL, soluble
form: solid
pka: 11.22±0.40(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G5918
Product name: GR 113808
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: G5918
Product name: GR 113808
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $689
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08120
Product name: GR113808 - CAS 144625-51-4 - Calbiochem
Packaging: 10MG
Price: $146
Updated: 2022/05/15

Cayman Chemical

Product number: 28733
Product name: GR 113808
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 28733
Product name: GR 113808
Packaging: 50mg
Price: $638
Updated: 2024/03/01

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GR 113808 Chemical Properties,Usage,Production

Uses

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca²⁺) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Definition

ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.

Biological Activity

Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.

Biochem/physiol Actions

GR 113808 is a 5-HT4 serotonin receptor antagonist.

storage

Store at RT

GR 113808 Preparation Products And Raw materials

Raw materials

Preparation Products

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GR 113808 Suppliers

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144625-51-4, GR 113808Related Search:

[1-(2-aminoethyl)-4-piperidinyl]methanol GR 113808 [3H]GR-113808

1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER

1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE

GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808

1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles

GR 113808

1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester

GR113808, selective 5-HT4 antagonist

144625-51-4

Serotonin receptor