GR 113808
- Product Name
- GR 113808
- CAS No.
- 144625-51-4
- Chemical Name
- GR 113808
- Synonyms
- GR 113808;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
- CBNumber
- CB8494704
- Molecular Formula
- C19H27N3O4S
- Formula Weight
- 393.5
- MOL File
- 144625-51-4.mol
GR 113808 Property
- Boiling point:
- 572.3±53.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 44 mg/mL, soluble
- form
- solid
- pka
- 11.22±0.40(Predicted)
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- G5918
- Product name
- GR 113808
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- G5918
- Product name
- GR 113808
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $689
- Updated
- 2024/03/01
- Product number
- 5.08120
- Product name
- GR113808 - CAS 144625-51-4 - Calbiochem
- Packaging
- 10MG
- Price
- $146
- Updated
- 2022/05/15
- Product number
- 28733
- Product name
- GR 113808
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 28733
- Product name
- GR 113808
- Packaging
- 50mg
- Price
- $638
- Updated
- 2024/03/01
GR 113808 Chemical Properties,Usage,Production
Uses
GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.
Definition
ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Biological Activity
Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.
Biochem/physiol Actions
GR 113808 is a 5-HT4 serotonin receptor antagonist.
storage
Store at RT