ChemicalBook > CAS DataBase List > GR 113808

GR 113808

Product Name
GR 113808
CAS No.
144625-51-4
Chemical Name
GR 113808
Synonyms
GR 113808;GR113808, selective 5-HT4 antagonist;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
CBNumber
CB8494704
Molecular Formula
C19H27N3O4S
Formula Weight
393.5
MOL File
144625-51-4.mol
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GR 113808 Property

Boiling point:
572.3±53.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 44 mg/mL, soluble
form 
solid
pka
11.22±0.40(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G5918
Product name
GR 113808
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
G5918
Product name
GR 113808
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$689
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08120
Product name
GR113808 - CAS 144625-51-4 - Calbiochem
Packaging
10MG
Price
$146
Updated
2022/05/15
Cayman Chemical
Product number
28733
Product name
GR 113808
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
28733
Product name
GR 113808
Packaging
50mg
Price
$638
Updated
2024/03/01
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GR 113808 Chemical Properties,Usage,Production

Uses

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Definition

ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.

Biological Activity

Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.

Biochem/physiol Actions

GR 113808 is a 5-HT4 serotonin receptor antagonist.

storage

Store at RT

GR 113808 Preparation Products And Raw materials

Raw materials

Preparation Products

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GR 113808 Suppliers

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144625-51-4, GR 113808Related Search:

[1-(2-aminoethyl)-4-piperidinyl]methanol GR 113808 [3H]GR-113808

  • 1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER
  • 1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE
  • GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
  • 1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles
  • GR 113808
  • 1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester
  • GR113808, selective 5-HT4 antagonist
  • 144625-51-4
  • Serotonin receptor