SCH 58261 Chemical Properties

Melting point:

223 °C

Density 

1.54±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO: >10 mg/mL, soluble

form 

solid

pka

2.78±0.30(Predicted)

color 

off-white

Safety Information

WGK Germany 

3

HS Code 

2934.99.3000

SCH 58261 Usage And Synthesis

Uses

SCH 58261 is a potent and selective A2A adenosine receptor antagonist.

Definition

ChEBI: LSM-3822 is a member of triazolopyrimidines.

Biological Activity

Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively.

Biochem/physiol Actions

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

storage

Store at RT

SCH 58261(160098-96-4)Related Product Information

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• 2-(2-FURANYL)-7-[3-(4-METHOXYPHENYL)PROPYL]-7H-PYRAZOLO[4,3-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-AMINE
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• SCH 58261
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