METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE Chemical Properties

Melting point:

36-38°

Boiling point:

120℃ (1 Torr)

Density 

1.156±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

pka

1.29±0.10(Predicted)

color 

cream

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT

HS Code 

2933399990

METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE Usage And Synthesis

Synthesis

Step 1 Preparation of methyl 2-methoxyisonicotinate: methyl 2-chloropyridine-4-carboxylate (5.23 g, 30.0 mmol) and sodium methanol (2.47 g, 45.0 mmol) were dissolved in 15 mL of dioxane and heated and refluxed for 1.5 hours. After the reaction was completed, it was cooled to room temperature, diluted with an appropriate amount of water and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 3.76 g (75% yield) of a yellow oily product, methyl 2-methoxyisonicotinate. Elemental analysis (C8H9NO3) Calculated values: C, 57.48; H, 5.43; N, 8.38. Measured values: C, 57.07; H, 5.54; N, 8.34.

References

[1] Patent: US6509361, 2003, B1

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