LY-53 857 MALEATE
LY-53 857 MALEATE Basic information
- Product Name:
- LY-53 857 MALEATE
- Synonyms:
-
- 6-methyl-1-(1-methylethyl)ergoline-8β-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate salt
- ly-53,857 maleate salt
- LY 53857
- CAS:
- 60634-51-7
- MF:
- C27H36N2O7
- MW:
- 500.59
- Mol File:
- 60634-51-7.mol
LY-53 857 MALEATE Chemical Properties
- solubility
- 0.1 M HCl: 25 mg/mL
- form
- solid
- color
- white
LY-53 857 MALEATE Usage And Synthesis
Uses
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT2 receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves[1].
References
[1] Cohen M L, et al. LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 227(2): 327-332. PMID:6313898
[2] Cohen M L, et al. Receptor specificity of the 5HT2 receptor antagonist, LY53857[J]. Drug development research, 1985, 5(4): 313-321.