Basic information Safety Supplier Related

NALOXONE METHIODIDE

Basic information Safety Supplier Related

NALOXONE METHIODIDE Basic information

Product Name:
NALOXONE METHIODIDE
Synonyms:
  • (17R)-17-allyl-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxo-morphinanium iodide
  • NALOXONE METHIODIDE QUATERNARY SALT OF N A
  • (5α,17r)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide
  • N-Methylnaloxonium iodide, (5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide
CAS:
93302-47-7
MF:
C20H24NO4.I
MW:
469.313
Mol File:
93302-47-7.mol
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NALOXONE METHIODIDE Chemical Properties

storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
tan
Water Solubility 
H2O: >10mg/mL
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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NALOXONE METHIODIDE Usage And Synthesis

Uses

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem/physiol Actions

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.

in vivo

Naloxone‐methiodide (10 mg/mL; 200 μL; i.p.), induces abdominal hypersensitivity in IL-10?/? mice with colitis[2].

Animal Model:Ten- to twelve-week-old IL-10 gene-deficient male (IL-10?/?) mice on C57BL/6 genetic background[2]
Dosage:10 mg/mL; 200 μL
Administration:Intraperitoneally
Result:In piroxicam-treated IL-10?/? mice induced abdominal pain.

NALOXONE METHIODIDESupplier

Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
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NALOXONE METHIODIDE(93302-47-7)Related Product Information