2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Chemical Properties

Melting point:

154-156 °C(Solv: ethanol (64-17-5))

Boiling point:

347.5±42.0 °C(Predicted)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: >10mg/mL

form 

Solid

pka

15.70±0.20(Predicted)

color 

Light brown to brown

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HazardClass 

IRRITANT

2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Usage And Synthesis

Uses

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].

Biological Activity

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but gre at selectivity over human Rnase H.

References

[1] Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3(10):635-44. DOI:10.1021/cb8001039

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