CBP-IN-1
CBP-IN-1 Basic information
- Product Name:
- CBP-IN-1
- Synonyms:
-
- CBP-IN-1
- CCS1477
- CCS-1477
- CBP inhibitor 1
- 2-Piperidinone, 1-(3,4-difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-, (6S)-
- CCS-1477(CBP-IN-1)
- CCS147
- CBP-IN-1 (CCS1477)
- CAS:
- 2222941-37-7
- MF:
- C30H32F2N4O3
- MW:
- 534.6
- Mol File:
- 2222941-37-7.mol
More
Less
CBP-IN-1 Chemical Properties
- Boiling point:
- 761.0±60.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol:100.0(Max Conc. mg/mL);187.06(Max Conc. mM)
- form
- A solid
- pka
- 4.40±0.10(Predicted)
- color
- White to off-white
- InChIKey
- SKDNDJWEBPQKCS-CLHVYKLBSA-N
- SMILES
- N1(C2=CC=C(F)C(F)=C2)[C@H](C2N([C@@H]3CC[C@@H](OC)CC3)C3=CC=C(C4=C(C)ON=C4C)C=C3N=2)CCCC1=O
More
Less
CBP-IN-1 Usage And Synthesis
Uses
(6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone is used for the treatment of genetic disease related to the expression of c9orf72 (brain expressed, associated with NEDD4)
in vivo
Inobrodib (10-30 mg/kg; oral gavage; 10 or 20 mg/kg daily (QD) or 30 mg/kg every other day (QOD) for 28 days) suppresses growth of a 22Rv1 mouse xenograft model with associated reduction in AR signaling[1].
?
Inobrodib (20 mg/kg; oral gavage; daily for 8 days) decreases AR and AR-V7 signaling and inhibits growth in a patient- derived model of lethal prostate cancer (NOD/SCID gamma (NSG) male castrated mice)[1].
| Animal Model: | Noncastrated male athymic nude mice[1] |
| Dosage: | 10-30 mg/kg |
| Administration: | Oral gavage; at 10 or 20 mg/kg daily (QD) or at 30 mg/kg every other day (QOD) for 28 days |
| Result: | Affected tumor growth at 10 mg/kg daily, 20 mg/kg daily, and 30 mg/kg every other day. |
CBP-IN-1Supplier
Nantong Hi-Future Biotechnology Co., Ltd Gold
- Tel
- 18051384581
- sales@chemhifuture.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai XingMo Biotechnology Co., Ltd.
- Tel
- +86 13524779951; 13524779951
- 2075692521@qq.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266