CTBP2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

CtBP2 and its homolog CtBP1 are transcriptional co-repressors originally identified as proteins that bind the carboxy-terminus of the human adenovirus E1A protein. CtBP proteins are thought to play important roles in regulating various developmental pathways because deletion of CtBP2 leads to embryonic lethality at E10.5 and is correlated with axial patterning defects. CtBP proteins regulate various oncogenic signaling pathways as promoters of epithelial-mesenchymal transition, apoptosis antagonists, and tumor suppressor genes repressors. The CtBP protein transcription co-repression activity results from interactions with numerous transcription factors and chromatin modulators, including the polycomb group proteins. Depending on the context, CtBP proteins interact with a short amino acid sequence motif to mediate repression of target genes through both histone deacetylase-dependent and independent mechanisms. CtBP proteins display a high sequence homology to the bacterial D-isomer-specific 2-hydroxyacid dehydrogenase enzymes. Research studies indicate that nuclear NADH levels regulate CtBP transcription repression activities, as NADH binding is required for CtBP2 homodimerization and transcription co-repressor activity.

References

[1] Chinnadurai, G. (2009) Cancer Res 69, 731-4.
[2] Boyd, J.M. et al. (1993) EMBO J 12, 469-78.
[3] Katsanis, N. and Fisher, E.M. (1998) Genomics 47, 294-9.
[4] Hildebrand, J.D. and Soriano, P. (2002) Mol Cell Biol 22, 5296-307.
[5] Battaglia, S. et al. (2010) Int J Cancer 126, 2511-9.
[6] Chinnadurai, G. (2002) Mol Cell 9, 213-24.
[7] Sewalt, R.G. et al. (1999) Mol Cell Biol 19, 777-87.
[8] Molloy, D.P. et al. (1998) J Biol Chem 273, 20867-76.
[9] Schaeper, U. et al. (1995) Proc Natl Acad Sci U S A 92, 10467-71.
[10] Kumar, V. et al. (2002) Mol Cell 10, 857-69.

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