SCAP antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Rat

Background

SREBP cleavage activating protein is a membrane-bound protein essential in regulating sterol regulatory element-binding protein processing. In cholesterol-starved cells, SREBPs move from the ER to the Golgi apparatus with the help of SCAP, where the precursor SREBPs are cleaved by site-1 and site-2 proteases. Released SREBP amino-terminal domains enter the nucleus and bind to sterol response elements located in the promoters of a number of genes responsible for the cholesterol synthesis. Research studies show that the SCAP/SREBP pathway is critical for diabetic fatty liver development and carbohydrate-induced hypertriglyceridemia in mice. In addition, the SCAP/SREBP pathway is required to protect cancer cells from lipotoxicity.

References

[1] Brown, M.S. and Goldstein, J.L. (1997) Cell 89, 331-40.
[2] Horton, J.D. et al. (2002) J Clin Invest 109, 1125-31.
[3] Moon, Y.A. et al. (2012) Cell Metab 15, 240-6.
[4] Williams, K.J. et al. (2013) Cancer Res 73, 2850-62.

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