LY3143921
LY3143921 Basic information
- Product Name:
- LY3143921
- Synonyms:
-
- LY3143921
- LY3143921 hydrate
- LY-3143921 hydrate,LY3143921 hydrate
- LY3143921 hydrate ，S9650
- CAS:
- 1627696-53-0
- MF:
- C16H14FN5O2
- MW:
- 327.32
- Mol File:
- 1627696-53-0.mol
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LY3143921 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 65 mg/mL (198.59 mM);Ethanol: 32 mg/mL (97.77 mM)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: Insoluble
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LY3143921 Usage And Synthesis
Uses
LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].
Biological Activity
LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.
in vivo
LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].
| Animal Model: | Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1] |
| Dosage: | 10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg |
| Administration: | Oral gavage; twice a day for 2 weeks |
| Result: | Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model. |
IC 50
Cdc7: 3.3 nM (IC50); pMCM2: 290 nM (IC50)
References
[1] Peter F. Gallagher, et al. Journal of Clinical Oncology. Volume 37, Issue 15_suppl.
LY3143921Supplier
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
- Tel
- 86-571-88216897,88216896 13588875226
- sales@hzclap.com
Nantong Hi-Future Biotechnology Co., Ltd
- Tel
- 18051384581
- sales@chemhifuture.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com