3,4-DIHYDROISOQUINOLINE Chemical Properties

Melting point:

251-254℃

Boiling point:

241.8±20.0℃ (760 Torr)

Density 

1.05±0.1 g/cm3 (20 ºC 760 Torr)

refractive index 

1.6041 (589.3 nm 30℃)

Flash point:

91.6±22.6℃

storage temp. 

2-8°C

pka

5.80±0.20(Predicted)

Safety Information

Hazard Codes 

T

Risk Statements 

22-24-36/38

Safety Statements 

26-36/37-45

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

3

3,4-DIHYDROISOQUINOLINE Usage And Synthesis

Uses

3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.

Uses

3,4-Dihydroisoquinoline can be used as a reactant to synthesize:

• 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
• 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
• 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8

3,4-DIHYDROISOQUINOLINE(3230-65-7)Related Product Information

• 7-Hydroxy-6-methoxy-3,4-dihydroisoquinoline
• 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
• 1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE
• 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline
• 1-METHYL-6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLINE, 99+%
• 3,4-DIHYDROISOQUINOLINE
• 3,4-Dihydro-2H-isoquinolin-1-one
• 7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• 1,2-Dihydroisoquinoline-1-one
• 1-Phenyl-3,4-dihydroisoquinoline
• 2-BENZYL-2,3-DIHYDROISOQUINOLIN-4(1H)-ONE HYDROCHLORIDE
• 7-Amino-1,2-dihydroisoquinolin-3-(4H)-one
• 6-Methoxy-3(2H)-isoquinolinone
• TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
• 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE
• 1-CYANO-2-BENZOYL-1,2-DIHYDROISOQUINOLINE
• TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
• 6,7-Dimethoxy-3,4-dihydroisoquinoline