FMOC-L-HYP(BOM)-OH Chemical Properties

Boiling point:

749.0±60.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

3.55±0.40(Predicted)

form 

Solid

color 

White to pink

FMOC-L-HYP(BOM)-OH Usage And Synthesis

Uses

Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

Synthesis

Step III: Preparation of Fmoc-(2S,4R)-(4-O-CO-NH-CH2-CH2-NH-Boc)-Pro-OH. the methyl ester obtained in step II was converted to free acid by hydrolysis reaction. This is done by adding 1N sodium hydroxide solution to a mixed solvent of 1,4-dioxane and water for the reaction. This step produced a mixture of H-(2S,4R)-(4-O-CO-NH-CH2-CH2-NH-Boc)-Pro-OH with the target product Fmoc-(2S,4R)-(4-O-CO-NH-CH2-CH2-NH-Boc)-Pro-OH. The reaction yield was 55%.

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

FMOC-L-HYP(BOM)-OH(187223-15-0)Related Product Information

• Fmoc-O-benzyl-L-tyrosine
• FMOC-PHE-OH
• Fmoc-Lys(Boc)-OH
• Boc-Hyp-OH
• (R)-1-FMOC-3-Pyrrolidinol
• (S)-1-FMOC-3-Pyrrolidinol
• BOC-HYP(BZL)-OH
• FMOC-L-HYP(BOM)-OH