H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Basic information
- Product Name:
- H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
- Synonyms:
-
- QRPRLSHKGPMPA
- [ALA13]-APELIN-13
- (ALA13)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
- (Ala13)-Apelin-13 (human, bovine, mouse, rat) trifluoroacetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH trifluoroacetate salt
- (Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH acetate salt
- H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
- [Ala13]Apelin-13, human, bovine, mouse, rat (F13A) (2)
- [Ala13]Apelin 13 (human, mouse, rat, bovine)
- CAS:
- 568565-11-7
- MF:
- C63H107N23O16S
- MW:
- 1474.73
- Product Categories:
-
- peptide
- Apelin receptor
- Mol File:
- 568565-11-7.mol
H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Chemical Properties
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 3.70±0.10(Predicted)
- form
- powder
- color
- white to beige
- Sequence
- Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala
H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Usage And Synthesis
Uses
(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].
Biological Activity
(Ala13)-Apelin-13 corresponds to Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions both in cultures and in animal studies in vivo.
in vivo
(Ala13)-Apelin-13 (1-300 pmol/60 nl; microinjected into the DVC) decreases gastric tone and motility in a dose-dependent manner in rats[1].
| Animal Model: | 250-300 g, Sprague-Dawley rats[1] |
| Dosage: | 1-300 pmol/60 nl |
| Administration: | Microinjected into the DVC (dorsal vagal complex (DVC) |
| Result: | Decreased gastric tone and motility in a dose-dependent manner with D50?≈?27 pmol for both antrum and corpus. |
References
[1] Bülbül M, et al. Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G201-G210. DOI:10.1152/ajpgi.00223.2017
[2] O'Harte FPM,et al. Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties. Biochem Pharmacol. 2017 Dec 15;146:165-173. DOI:10.1016/j.bcp.2017.10.002
H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OHSupplier
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H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH(568565-11-7)Related Product Information
- GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
- APELIN-15 (63-77)
- H-LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
- APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE
- APELIN (65-77) (N15-ARG 66) [HOMO SAPIENS]/[MUS MUSCULUS]/[BOS TAURUS]
- H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH