APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE Chemical Properties

Density 

1.49±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at -20°C

form 

Powder

color 

White to off-white

Water Solubility 

Soluble to 1.20 mg/ml in water

Sequence

H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE Usage And Synthesis

Uses

Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

IC 50

HIV-1; HIV-2

storage

Store at -20°C

References

[1] Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476. DOI:10.1006/bbrc.1998.9489
[2] Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172. DOI:10.1046/j.1471-4159.2003.01587.x
[3] Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18. DOI:10.1016/s0014-5793(00)01487-3

APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE(217082-57-0)Related Product Information

• H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
• H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
• GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
• H-LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
• APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE