Basic information Safety Supplier Related

H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH

Basic information Safety Supplier Related

H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH Basic information

Product Name:
H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
Synonyms:
  • (Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat)
  • Apelin-12,(Des-Gln1)-Apelin-13
  • Apelin-12 (human, bovine, mouse, rat) H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
  • Apelin-12 (huMan, bovine, Mouse, rat) (Des-Gln1)-Apelin-13 (huMan, bovine, Mouse, rat), Apelin Precursor (66-77) (huMan, bovine, Mouse, rat), Preproapelin (66-77) (huMan, bovine, Mouse, rat)
  • H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
  • (DES-GLN1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
  • APELIN PRECURSOR (66-77) (HUMAN, BOVINE, MOUSE, RAT)
  • APELIN 12
CAS:
229961-08-4
MF:
C64H103N21O14S
MW:
1422.7
Product Categories:
  • Apelin receptor
  • peptide
  • Elisa Kit-Mouse Elisa Kit
Mol File:
229961-08-4.mol
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H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH Chemical Properties

RTECS 
CD7310000
storage temp. 
-15°C
form 
Lyophilized powder
color 
White to off-white
Sequence
H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
InChIKey
KIODTAJAFBDDGP-TZIGXLGFSA-N
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H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH Usage And Synthesis

Uses

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

IC 50

HIV-1

References

[1] Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. DOI:10.4103/0976-500X.114600
[2] Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250. DOI:10.1007/s11010-014-2008-4
[3] Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. DOI:10.26355/eurrev_201806_15273
[4] Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78. DOI:10.1016/j.regpep.2011.12.002

H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OHSupplier

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