Ethyl N-piperazinecarboxylate Chemical Properties

Melting point:

120 °C

Boiling point:

273 °C (lit.)

Density 

1.08 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.477(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Oily Liquid

pka

8.50±0.10(Predicted)

color 

Clear light yellow

Water Solubility 

soluble

BRN 

125780

CAS DataBase Reference

120-43-4(CAS DataBase Reference)

NIST Chemistry Reference

1-Piperazinecarboxylic acid, ethyl ester(120-43-4)

EPA Substance Registry System

1-Piperazinecarboxylic acid, ethyl ester (120-43-4)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

23-24/25-37/39-26-36

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

TL1378000

Hazard Note 

Toxic

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29335995

MSDS

• Language:English Provider:Ethyl N-piperazinecarboxylate
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Ethyl N-piperazinecarboxylate Usage And Synthesis

Chemical Properties

clear light yellow oily liquid

Uses

Intermediate.

Synthesis

Piperazine (2 g, 23.2 mmol) and deionized water (10 mL) were added to a reaction flask and stirred at 25 °C until completely dissolved, then cooled to 0 °C. A methanol solution (20 mL) of ethyl chloroformate (1.26 g, 11.6 mmol) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction system was warmed to 25 °C and stirring was continued for 4 hours. Upon completion of the reaction, saturated aqueous sodium chloride solution (30 mL) and dichloromethane (200 mL) were added to the reaction solution for extraction and separation. The organic layer was collected and dried with anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure, and the resulting crude product was purified by column chromatography (eluent: dichloromethane/methanol, 40:1, v/v/v/v) to give ethyl N-piperazinecarboxylate (0.62 g, 33.7% yield) as a white solid.

References

[1] Patent: CN103664899, 2017, B. Location in patent: Paragraph 0465-0469
[2] Patent: CN103664925, 2018, B. Location in patent: Paragraph 0458; 0461; 0462
[3] Journal of the Chemical Society, 1929, p. 50
[4] Journal of Organic Chemistry, 1948, vol. 13, p. 134,138
[5] Chemische Berichte, 1933, vol. 66, p. 113,116

Ethyl N-piperazinecarboxylate(120-43-4)Related Product Information

• RESMETHRIN
• Ethanol
• Cyclohexanecarboxylic acid ethyl ester
• Piperazine
• Trinexapac-ethyl
• Oxyfluorfen
• Urethane
• Triethyl orthoformate
• Ethyl cyanoformate
• Ethyl formate
• Ethyl propionate
• 2-Ethoxyethanol
• 2-Ethylhexyl ferulate
• ISOXADIFEN-ETHYL
• Piperacillin
• Ethyl acetate
• Ethylparaben
• Ethyl chloroformate