2-(BENZYLOXY)-1-ETHANAMINE HYDROCHLORIDE Chemical Properties

Melting point:

142 °C

storage temp. 

Sealed in dry,Room Temperature

form 

liquid

color 

Colorless

InChI

InChI=1S/C9H13NO.ClH/c10-6-7-11-8-9-4-2-1-3-5-9;/h1-5H,6-8,10H2;1H

InChIKey

AFQMWBUNDONXED-UHFFFAOYSA-N

SMILES

C(C1C=CC=CC=1)OCCN.Cl

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36-43

Safety Statements 

26-36

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2922390090

2-(BENZYLOXY)-1-ETHANAMINE HYDROCHLORIDE Usage And Synthesis

Uses

2-Benzyloxyethylamine Hydrochloride is used to synthesize single and double-chain fluorocarbon and hydrocarbon galactosyl amphiphiles with anti-HIV-1 activities.

Synthesis

General procedure for the synthesis of 2-benzyloxyethylamine hydrochloride from the compound (CAS: 634925-24-9): to a solution of ether (10 mL) of the product obtained in step 2 (4 g, 15.93 mmol) was slowly added an ether solution (20 mL) of 4N HCl. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered and the filter cake was washed with hexane. Subsequently, the product was dried under vacuum to afford 2-benzyloxyethylamine hydrochloride in the form of an off-white solid (2 g, 83% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 3.01 (t, J = 5.20 Hz, 2H), 3.63 (t, J = 5.60 Hz, 2H), 4.54 (s, 2H), 7.35-7.36 (m, 5H), 8.01 (bs, 3H).

References

[1] Patent: WO2015/27021, 2015, A1. Location in patent: Page/Page column 87 ;88
[2] Carbohydrate Research, 2000, vol. 327, # 3, p. 223 - 260
[3] Patent: US2004/10007, 2004, A1. Location in patent: Page 64-65; 82

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