Basic information Safety Supplier Related

FURIN INHIBITOR II

Basic information Safety Supplier Related

FURIN INHIBITOR II Basic information

Product Name:
FURIN INHIBITOR II
Synonyms:
  • HEXA-D-ARGININE
  • H-(D)RRRRRR-NH2
  • FURIN INHIBITOR II
  • H-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-NH2
  • Hexa-D-arginine aMide
  • D-ArgininamideD-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-alanine
  • Furin Inhibitor II, >98%
  • Hexa-D-arginine,RRRRRR
CAS:
673202-67-0
MF:
C36H75N25O6
MW:
954.14
Mol File:
673202-67-0.mol
More
Less

FURIN INHIBITOR II Chemical Properties

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
H2O : 50 mg/mL (52.40 mM; Need ultrasonic)DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)
form 
lyophilized
pka
13.24±0.46(Predicted)
Water Solubility 
Soluble to 2 mg/ml in water
More
Less

Safety Information

WGK Germany 
3
More
Less

FURIN INHIBITOR II Usage And Synthesis

Uses

Furin Inhibitor II has been used as a furin inhibitor:

  • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
  • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
  • in furin cleavage assay.

General Description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein?4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases?and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

storage

Store at -20°C

FURIN INHIBITOR IISupplier

Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Email
sales@reading-chemicals.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com