FURIN INHIBITOR II Chemical Properties

Density 

1.59±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

H2O : 50 mg/mL (52.40 mM; Need ultrasonic)DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)

form 

lyophilized

pka

13.24±0.46(Predicted)

color 

White to off-white

Water Solubility 

Soluble to 2 mg/ml in water

Safety Information

WGK Germany 

3

FURIN INHIBITOR II Usage And Synthesis

Uses

Furin Inhibitor II has been used as a furin inhibitor:

• to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
• to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
• in furin cleavage assay.

General Description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein?4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases?and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

storage

Store at -20°C

FURIN INHIBITOR II(673202-67-0)Related Product Information

• H-GLU-LEU-ASP-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-VAL-GLU-PHE-GLY-GLY-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-OH
• FURIN INHIBITOR II
• C(NPYS)RRRRRRRRR-NH2