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Calcium bis(cyclohexylsulphamate)

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Calcium bis(cyclohexylsulphamate) Basic information

Product Name:
Calcium bis(cyclohexylsulphamate)
Synonyms:
  • cacyclamate
  • calciumcyclohexanesulfamate
  • calciumcyclohexanesulphamate
  • calciumcyclohexylsulfamate
  • calciumcyclohexylsulphamate
  • calciumsucaryl
  • cyclamate,calciumsalt
  • cyclamicacidhemicalcium
CAS:
139-06-0
MF:
C6H15CaNO3S
MW:
221.33
EINECS:
205-349-4
Mol File:
139-06-0.mol
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Calcium bis(cyclohexylsulphamate) Chemical Properties

Merck 
13,1666
EPA Substance Registry System
Calcium cyclamate(1:2) (139-06-0)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
36/37/38
Safety Statements 
26-36
RTECS 
GV7100000
Hazardous Substances Data
139-06-0(Hazardous Substances Data)
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Calcium bis(cyclohexylsulphamate) Usage And Synthesis

Chemical Properties

White crystals or powder; nearly odor- less; very sweet taste. Freely soluble in water (solu- tions are neutral to litmus); almost insoluble in alco- hol, benzene, chloroform, and ether; p H (10% solu- tion) 5.5–7.5. Sweetening power approximately 30 times that of sucrose.

Originator

Sucaryl Calcium,Abbott,US,1953

Uses

Nonnutritive sweetener.

Uses

Calcium bis(N-Cyclohexylsulfamate) is used in method for regulating citrus summer light by regulating cyclamate calcium nutrition.

Manufacturing Process

220 parts by weight, 2.22 mols, of cyclohexylamine and 57 parts by weight, 0,50 mol, of ammonium sulfamate were mixed at room temperature and heated with agitation. At the end of one-half hour of heating the temperature had reached 110°C and approximately one-half mol of ammonia had been evolved. Heating was continued under reflux at 133°C for 22 additional hours. A second half-mol of ammonia was liberated. The ammonia yield was 100%.
The reaction mixture was cooled to 100°C. To the mixture was added a water slurry containing 20.3 parts by weight, 0.55 equivalent, of calcium hydroxide and 700 parts by weight of water. Cyclohexylamine was then removed by azeotropic distillation with water.
The amine which was recovered can be reused after drying.
The residue from the distillation was evaporated to dryness in a vacuum oven at 50°C and the resulting product analyzed. The product weighing 105.5 parts by weight, 0.488 equivalent, was obtained which is a 98% yield of the technical calcium cyclohexylsulfamate dihydrate.

Therapeutic Function

Pharmaceutic aid

Hazard

Not permitted for use in foods and soft drinks, because of suspected carcinogenicity.

Safety Profile

Poison by ingestion and intravenous routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also CALCIUM COMPOUNDS.

Calcium bis(cyclohexylsulphamate) Preparation Products And Raw materials

Raw materials

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