Basic information Safety Supplier Related

FENTIAZAC

Basic information Safety Supplier Related

FENTIAZAC Basic information

Product Name:
FENTIAZAC
Synonyms:
  • FENTIAZAC
  • 4-(4-chlorophenyl)-2-phenyl-5-thiazoleaceticacid
  • 4-(p-chlorophenyl)-2-phenyl-5-thiazoleaceticaci
  • 4-(p-chlorophenyl)-2-phenyl-5-thiazoleaceticacid
  • 4-(p-chlorophenyl)-2-phenylthiazole-5-aceticacid
  • 4-(4-Chlorlphenyl)-2-phenyl-5-thiazoleacetic acid
  • [4-(4-Chloro-phenyl)-2-phenyl-thiazol-5-yl]-acetic acid
  • br700
CAS:
18046-21-4
MF:
C17H12ClNO2S
MW:
329.8
EINECS:
241-958-1
Mol File:
18046-21-4.mol
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FENTIAZAC Chemical Properties

Melting point:
162°C
Boiling point:
556.2±60.0 °C(Predicted)
Density 
1.1592 (rough estimate)
refractive index 
1.6100 (estimate)
pka
3.89±0.10(Predicted)
Water Solubility 
31.66mg/L(25 ºC)
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Safety Information

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Toxicity
LD50 in rats, mice (mg/kg): 661, 692 orally (Marmo)
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FENTIAZAC Usage And Synthesis

Originator

Norvedan,LPB,Italy,1975

Uses

Anti-inflammatory.

Manufacturing Process

13.6 g methyl 3-(p-chlorobenzoyl)-3-bromopropionate in 30 ml methanol are added to a solution of 5.6 g potassium thioacetate in 30 ml methanol. Immediate precipitation of KBr is observed. The suspension is refluxed for 10 minutes.
It is cooled to ambient temperature, filtered, and the methanol is evaporated to dryness. 13.2 g methyl 3-(p-chlorobenzoyl)-3-thioacetylpropionate in the form of a chromatographically pure orange-colored oil are obtained.
A suspension of 13.2 g methyl 3-(p-chlorobenzoyl)-3-thioacetylpropionate is agitated in 500 ml of a 2 N aqueous solution of KOH for 6 hours at ambient temperature in an atmosphere of nitrogen, followed by extraction with ethyl ether. The aqueous phase, adjusted to a pH equal to 2 with 2N HCl, is extracted with ethyl ether which was washed with water, dried over Na2SO4, and finally evaporated to dryness
9.8 g of crude 3-(p-chlorobenzoyl)-3-mercaptopropionic acid are obtained. By recrystallizing from isopropyl ether there are obtained 8.6 g of pure product, MP 96°C to 97°C (yield: 79%).
1.7 ml benzonitrile and 5.05 ml diethylamine are added to a solution of 4 g 3- (p-chlorobenzoyl)-3-thiol-propionic acid in 50 ml ethanol. The solution is agitated at ambient temperature for 60 minutes in an atmosphere of nitrogen. It is then evaporated to a syrupy consistency and 60 ml 50% aqueous acetic acid are added, whereupon the mixture is refluxed for 60 minutes. It is evaporated to a small volume, adjusted to a pH equal to 8 with a saturated solution of sodium bicarbonate and then extracted with ethyl ether. The aqueous phase is acidified with 2N HCl (Congo red), and then again extracted with ethyl ether. It is dried over Na2SO4 and evaporated to dryness. The evaporation residue is recrystallized from benzene and 4 g 4-(p-chlorophenyl)- 2-phenyl-thiazol-5-yl-acetic acid are obtained (MP = 152°C to 154°C, yield - 74.3%).

Therapeutic Function

Analgesic, Antipyretic, Antiinflammatory

FENTIAZAC Preparation Products And Raw materials

Raw materials

FENTIAZACSupplier

TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Shanghai Haohong Scientific Co., Ltd.
Tel
400-8210725
Email
cb_no5@leyan.com
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1005@dideu.com