EC 4.4.1.5 Chemical Properties

storage temp. 

2-8°C

form 

buffered aqueous glycerol solution

Safety Information

WGK Germany 

3

MSDS

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EC 4.4.1.5 Usage And Synthesis

Uses

Glyoxalase I from Saccharomyces cerevisiae has been used as a standard in Glyoxalase I assay for C.?dilatata?females and brooded encapsulated embryos. It has also been used as a standard for calibration curve generation for quantifying glyoxalase I from brain tissues and cerebral microvessels.

General Description

Glyoxalase detoxification system consists of glyoxalase (GLO)-I and GLO-II. GLO-I is a cytosolic, 42 kDa, dimeric Zn²⁺ metalloenzyme.

Biochem/physiol Actions

Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner.

EC 4.4.1.5(9033-12-9)Related Product Information

• L-Glutathione
• Methylglyoxal
• Glutathione