EC 4.4.1.5
EC 4.4.1.5 Basic information
- Product Name:
- EC 4.4.1.5
- Synonyms:
-
- EC 4.4.1.5
- GLYOXALASE I
- S-LACTOYL-GLUTATHIONE METHYLGLYOXAL-LYASE [ISOMERIZING]
- glyoxalase I grade iv from yeast
- glyoxalase I grade X from yeast
- glyoxalase i from saccharomyces cerevisiae
- glyoxylase I
- CAS:
- 9033-12-9
- MW:
- 0
- Mol File:
- Mol File
EC 4.4.1.5 Chemical Properties
- storage temp.
- 2-8°C
- form
- buffered aqueous glycerol solution
MSDS
- Language:English Provider:SigmaAldrich
EC 4.4.1.5 Usage And Synthesis
Uses
Glyoxalase I from Saccharomyces cerevisiae has been used as a standard in Glyoxalase I assay for C.?dilatata?females and brooded encapsulated embryos. It has also been used as a standard for calibration curve generation for quantifying glyoxalase I from brain tissues and cerebral microvessels.
General Description
Glyoxalase detoxification system consists of glyoxalase (GLO)-I and GLO-II. GLO-I is a cytosolic, 42 kDa, dimeric Zn2+ metalloenzyme.
Biochem/physiol Actions
Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner.