3-(2,2,3,3-TETRAFLUOROPROPOXY)-1,2-EPOXYPROPANE Chemical Properties

Boiling point:

50 °C/4 mmHg (lit.)

Density 

1.327 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.366(lit.)

Flash point:

175 °F

form 

liquid

color 

Clear, colourless

InChI

InChI=1S/C6H8F4O2/c7-5(8)6(9,10)3-11-1-4-2-12-4/h4-5H,1-3H2

InChIKey

DATKALAKXGFGPI-UHFFFAOYSA-N

SMILES

O1CC1COCC(F)(F)C(F)F

CAS DataBase Reference

19932-26-4(CAS DataBase Reference)

EPA Substance Registry System

((2,2,3,3-Tetrafluoropropoxy)methyl)oxirane (19932-26-4)

Safety Information

Hazard Codes 

Xi,F,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

IRRITANT, FLAMMABLE

HS Code 

2932990090

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral

MSDS

• Language:English Provider:SigmaAldrich

3-(2,2,3,3-TETRAFLUOROPROPOXY)-1,2-EPOXYPROPANE Usage And Synthesis

Uses

Glycidyl 2,2,3,3-tetrafluoropropyl ether is used as pharmaceutical intermediate.

Synthesis

In a vessel with a separator, a dropping funnel and a stirring device, 200 g (2.16 mol) of 1,2-epichlorohydrin (1,2-epichlorohydrin:tetrafluoropropanol is 4.8:1) and 60 mL of cyclohexane were added, and stirred and heated at 350 raps/min until the cyclohexane refluxed. Then, 65 g of 40% aqueous potassium hydroxide and 60 g (0.45 mol) of tetrafluoropropanol were added dropwise to the reaction system, and the water was removed while the reaction was going on, and the reaction was completed when the aqueous potassium hydroxide and the tetrafluoropropanol were finished, and the reaction ended when there was no water out of the reaction. After cooling, filtering to remove potassium chloride, the mother liquor was heated to 65 ?? at atmospheric pressure to remove cyclohexane in the reaction solution, when cyclohexane was not distilled, the temperature was lowered to 30 ??, and then converted to reduced-pressure distillation, and pressure was adjusted so that the temperature of the distillation system was controlled at 65 ??, to recover the excess of 1,2-epichlorohydrin, and then, the fractions of 120-130 ??/250-300 Pa were collected, and the crude 3-(2,2,3,3) 3,3,3-tetrafluoropropoxy)-1,2-propene oxide was distilled under reduced pressure, and the fraction at 125-127 ??C/250-300 Pa was collected to obtain 70.5 g of 3-(2,2,3,3-tetrafluoropropoxy)-1,2-propene oxide, with a yield of 83.5% in terms of tetrafluoropropanol.

3-(2,2,3,3-TETRAFLUOROPROPOXY)-1,2-EPOXYPROPANE(19932-26-4)Related Product Information

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