Basic information Industrial brominating agent and disinfectant Physical and Chemical Properties Sterilization Mechanism Synthesis of 1,3-Dibromo-5,5-dimethylhydantoin Uses Chemical Properties Production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage properties Extinguishing media Safety Supplier Related
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Basic information Industrial brominating agent and disinfectant Physical and Chemical Properties Sterilization Mechanism Synthesis of 1,3-Dibromo-5,5-dimethylhydantoin Uses Chemical Properties Production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage properties Extinguishing media Safety Supplier Related

1,3-Dibromo-5,5-dimethylhydantoin Basic information

Product Name:
  • dibromantine
  • 1,3-Dibromo-5
  • 1,3-dibrom0-5,5-dimethylhydantoin
  • 1,3-dibromo-5,5-dimethyl-4-imidazolidinedione
  • 1,3-dibromo-5,5-dimethyl-hydantoi
  • dibromohydantoin
  • Dimethyl Dibromohydantoin
Product Categories:
  • Miscellaneous
  • Bromination
  • Halogenation
  • Synthetic Organic Chemistry
  • Water treatment chemicals
  • water treatment
  • Nitrogen cyclic compounds
  • Non-Chiral heterocyclic compounds
  • bc0001
  • 77-48-5
Mol File:

1,3-Dibromo-5,5-dimethylhydantoin Chemical Properties

Melting point:
197-199 °C (dec.)(lit.)
Boiling point:
250.2±23.0 °C(Predicted)
1.00 g/cm3 (25℃)
refractive index 
1.6220 (estimate)
Flash point:
155 °C
storage temp. 
Store below +30°C.
Cream or light yellow
Water Solubility 
Soluble in Alcohol, Ether, Benzene. Insoluble in Water.
Moisture Sensitive
197-199 ºC
CAS DataBase Reference
77-48-5(CAS DataBase Reference)
EPA Substance Registry System
1,3-Dibromo-5,5-dimethylhydantoin (77-48-5)

Safety Information

Hazard Codes 
Risk Statements 
Safety Statements 
UN 3087 5.1/PG 2
WGK Germany 
Hazard Note 
HS Code 



1,3-Dibromo-5,5-dimethylhydantoin Usage And Synthesis

Industrial brominating agent and disinfectant

1, 3-Dibromo-5, 5-dimethylhydantoin is primarily used as an industrial brominating agent and antiseptic disinfectant. It is a very useful kind of brominating agent. Compared with brominating agent such as N-bromoacetamide, N-bromosuccinimide, etc. it has a lot of advantages including high content of active bromine, excellent storage stability, and economic application. Therefore, it is widely applied to chemical and pharmaceutical industry such as being used for the bromination of allyl and benzyl compounds as well as aromatic ring, the addition reaction of the bromine in double bond and hydrogen bromide as well as the selective oxidation of secondary alcohols; in addition, it is also a kind of efficient and safe disinfectant with a strong efficacy in killing fungi, bacteria and viruses as well as in killing the adverse algae in the water. It can be applied to the prevention and treatment of many kinds of diseases in aquaculture related to fish, shrimp, frogs and turtles as well as the disinfection of swimming pool, fruit preservation and algae killing via industrial recycled water algae and daily disinfection. For example, the experts in the Beijing SARS prevention and control working panel had proposed for using the 1, 3-Dibromo-5, 5-dimethylhydantoin solution with effective bromine being 500~1000mg/L for spray, mopping and cleaning, having the disinfection for 10~15min to prevent SARS.

Physical and Chemical Properties

1, 3-Dibromo-5, 5-dimethylhydantoin has the English abbreviation be DBDMH with pure product being white solid and the mp being 196~198 ℃. The industrial products appear as a pale yellow solid with a mp of 194~197 ℃; it is soluble in chloroform, ethanol, acetone and other organic solvents, slightly soluble in water with 1 L water being able to dissolve 2.2 g of DBDMH at 20℃ with the pH of 0.1% aqueous solution being 2.6; It is prone to be subject to decomposition in strong acid or alkali; it is stable when dry and is easy to absorb moisture with partially hydrolysis after moisture absorption; it has a slight pungent odor with the active bromine content being 54% to 55%.

Sterilization Mechanism

DBDMH, upon hydrolysis in water, can mainly form hypobromous acid and can release bromine in the form of hypobromous acid. DBDMH, due to able to release bromine in a high reaction rate, can continuously release Br-ions in the water, further playing a bactericidal effect. However, other kinds of halogenated hydantoin, such as 1, 3-Dibromo-5, 5-dimethylhydantoin or bromochlorohydantoin, release the chlorine in a very slow rate, leading to that the time for reaching the peak of sterilization in the water is lagging behind, therefore, DBDMH usually has a higher efficiency than other kind of halogenated hydantoin at relatively rapid bactericidal conditions.

Synthesis of 1,3-Dibromo-5,5-dimethylhydantoin

Adding an appropriate amount of water to dimethyl hydantoin, control the temperature at about 30 ℃ for stirring of 30min until all the dimethyl hydantoin is dissolved. Add drop wise of appropriate amount of bromine within a certain period of time and then have reaction for several hours. After the completion of the reaction, cool the solution, crystallize using ethanol, filter, and dry with the light-yellow solid being finished product of DBDMH.

The optimal condition for experimentally determination and synthesis of DBDMH is: the optimum molar ratio of DMH to bromine is 1: 2.0; the solvent amount is 80 mL (water) /0.1mol (Hein); the reaction temperature should be about 30 ℃; Reaction time is around 5min with the yield of 1,3-dibromo-5,5-dimethylhydantoin being up to 80%.


DBDMH is an important chemical product and has been widely applied in chemical, pharmaceutical and agricultural industries with various kinds of advantages including excellent stability, high content of bromine and high reactive activity. Currently, the combined formulation between DBDMH and other halogenated hydantoin for application has become a hotspot in recent years such as the combined application of BCDMH and DBDMH as well as the combined application of DCDMH and DBDMH. For the combined formulation of DBDMH and other halogenated hydantoin, one critical factor is the ratio between effective chlorine and effective bromine. For example, at pH 7.1, compound formulation with the same dose of BCDMH and DBDMH has a significantly higher bactericidal efficacy than DBDMH alone or BCDMH alone. Many domestic and foreign experts believe that the most significant oxidizing biocide is the compound halogenated compound formulation combining BCDMH and DBDMH. In agriculture, DBDMH is mainly used for aquaculture including pond disinfection, prevention of water disinfection, disease treatment, etc., and is not affected by water quality, salinity, pH, temperature, and other organic compounds during usage. In addition, there has been already cases in which people has applied DBDMH as high-efficiency and low-toxicity disinfectant for combined formulation with stearic acid monoglyceride and Tween-80 and applied to the surface of the orange for preventing mold and preservation, and has already achieved excellent results. We can expect that this preservative can also be used for storage and preservation of other fruits and vegetables. Therefore, with the continuous development of chemical and pharmaceutical industry and increasing people's living standards, it is expected that the application range and demand of DBDMH will increase greatly.

Chemical Properties

It appears as white or light yellow crystalline powder.

Production method

It is obtained through the bromination of 5, 5-dimethyl hydantoin. Mix the 5, 5-dimethyl hydantoin, sodium carbonate, sodium hydroxide and water together, add bromine slowly under cooling. After the addition, it was poured into water with the crystal filtered out after standing being the crude product. The crude product was further dissolved in acetone for decolorizing and filtrating. The filtrate was poured into water to give white crystalline which is the finished product.



Toxicity grading

Highly toxic

Acute toxicity

Oral-rat LD50: 250 mg/kg.

Flammability and hazard characteristics

It is flammable with burning discharging spicy smoke of bromide and nitrogen oxides.

Storage properties

Warehouse: cold, ventilated and dry; store it separately from food raw materials.

Extinguishing media

Water, carbon dioxide, dry, sandy soil.

Chemical Properties



Brominating agent. Analytical reagent for determination of iodide and organic iodine, and for identification tests.


It is used for drinking water purification, recreational water treatment, as a bleaching agent in pulp and paper mills, and for treating industrial/commercial water cooling systems. It is an efficient and selective agent for the oxidation of thiols to disulfides in solution or under solvent-free conditions.

Purification Methods

Recrystallise it from H2O. Its solubility in CCl4 is 0.003 mol/L at 25o and 0.024 mol/L at 76.5o. [Beilstein 24 III/IV 1101.]

1,3-Dibromo-5,5-dimethylhydantoin Preparation Products And Raw materials

Raw materials

Preparation Products


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