(2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

(2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE Usage And Synthesis

Synthesis

To 2,4,6-trichloropyridine (10.0 g, 55.6 mmol) and dimethylamine hydrochloride (4.5 g, 55.6 mmol) in N,N-dimethylformamide (DMF, 80 mL) was added triethylamine (Et3N, 8.0 g, 55.6 mmol). The reaction mixture was placed in a sealed tube, heated to 80 °C and maintained for 8 hours. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product 2,6-dichloro-N,N-dimethylpyridin-4-amine (12-TT, 4.0 g) as a white solid.1H-NMR (DMSO-d6, 400 MHz): δ=6.66 (s, 2H), 2.99 (s, 6H).

References

[1] Patent: WO2014/31784, 2014, A1. Location in patent: Paragraph 0705