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Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester

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Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester Basic information

Product Name:
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
Synonyms:
  • Thalidomide-O-C8-Boc
  • Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
  • Thalidomide-4-O-C8-COO(t-Bu)
  • 2-(2,6-Dioxo-3-piperidinyl)-4-(nonyloxy)-1H-isoindole-1,3(2H)-dione
  • Thalidomide-O-C8-t-butyl ester
  • tert-Butyl 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanoate
  • tert-butyl 8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butanoate
CAS:
2225148-52-5
MF:
C26H34N2O7
MW:
486.56
Mol File:
2225148-52-5.mol
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Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester Chemical Properties

Boiling point:
658.5±55.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
storage temp. 
-20°C, stored under nitrogen
form 
Solid
pka
10.70±0.40(Predicted)
color 
White to off-white
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Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester Usage And Synthesis

Uses

Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs[1].

IC 50

Cereblon

References

[1] Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1.

Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl esterSupplier

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Shanghai Haohong Pharmaceutical Co., Ltd.
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Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester(2225148-52-5)Related Product Information