Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Chemical Properties

Boiling point:

734.4±60.0 °C(Predicted)

Density 

1.323±0.06 g/cm3(Predicted)

storage temp. 

-20°C, stored under nitrogen

form 

Solid

pka

10.74±0.40(Predicted)

color 

Light yellow to yellow

Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Usage And Synthesis

Uses

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the?Thalidomide?based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].

IC 50

Cereblon

References

[1] David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743. DOI:10.1002/anie.201611281

Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester(2097509-40-3)Related Product Information

• tert-butyl (8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamate
• Thalidomide-NH-PEG1-NH-Boc
• N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester
• 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester
• Thalidomide-NH-C3-NH-Boc
• N-[2-Aminoethyl] Pomalidomide Trifluoroacetic Acid Salt
• Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester
• Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
• 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
• Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
• Thalidomide-O-C6-acid
• Thalidomide-4-O-C8-NH2
• Thalidomide-O-C3-acid
• 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
• Thalidomide-4-O-C6-NH2 hydrochloride
• Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
• Thalidomide-O-C5-acid