Thalidomide-NH-PEG1-NH-Boc Chemical Properties

Boiling point:

715.3±60.0 °C(Predicted)

Density 

1.346±0.06 g/cm3(Predicted)

pka

10.74±0.40(Predicted)

Thalidomide-NH-PEG1-NH-Boc Usage And Synthesis

Uses

Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

IC 50

Cereblon

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Thalidomide-NH-PEG1-NH-Boc(2154342-17-1)Related Product Information

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