Thalidomide-4-O-C6-NH2 hydrochloride
Thalidomide-4-O-C6-NH2 hydrochloride Basic information
- Product Name:
- Thalidomide-4-O-C6-NH2 hydrochloride
- Synonyms:
-
- 4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
- 4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- -ether-alkylC6-amine
- Thalidomide-O-C6-NH2 hydrochloride
- 1H-?Isoindole-?1,?3(2H)?-?dione, 4-?[(6-?aminohexyl)?oxy]?-?2-?(2,?6-?dioxo-?3-?piperidinyl)?-?, hydrochloride
- 4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
- 3-dione hydrochloride
- 4-((6-aminohexyl)oxy)-2-(2
- CAS:
- 2245697-88-3
- MF:
- C19H24ClN3O5
- MW:
- 409.87
- Mol File:
- 2245697-88-3.mol
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Thalidomide-4-O-C6-NH2 hydrochloride Chemical Properties
- storage temp.
- 2-8°C, sealed storage, away from moisture and light
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Off-white to gray
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Thalidomide-4-O-C6-NH2 hydrochloride Usage And Synthesis
Description
Thalidomide-O-C6-Amine HCl is a functionalized cereblon ligand used for PROTAC research. It incorporates an E3 ligase ligand and a C6 alkyl linker to conjugate to a target protein.
Uses
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].
IC 50
Cereblon
storage
Store at -20°C
References
[1] Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274. DOI:10.1038/nature21688
Thalidomide-4-O-C6-NH2 hydrochlorideSupplier
ChemShuttle, Inc.
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- 0510-83588313-811 18800520310
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Bide Pharmatech Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Xi'an Confluore Biological Technology Co., Ltd.
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Shanghai Hongye Biotechnology Co. Ltd
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- 400-9205774
- sales@glpbio.cn
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Thalidomide-4-O-C6-NH2 hydrochloride(2245697-88-3)Related Product Information
- Thalidomide-O-C5-acid
- Thalidomide-O-C3-acid
- Thalidomide-O-C6-acid
- Thalidomide-O-C10-NH2
- Thalidomide-O-C6-NH2
- Thalidomide-linker 9
- Thalidomide-linker 6
- Thalidomide-O-C6-NH2 TFA
- Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
- Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
- Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
- Thalidomide-4-O-C8-NH2
- 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione