5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Chemical Properties

Boiling point:

590.1±50.0 °C(Predicted)

Density 

1.672±0.06 g/cm3(Predicted)

pka

10.52±0.40(Predicted)

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Usage And Synthesis

Uses

Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.

IC 50

Cereblon

References

[1] Zhang NN, et, al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.e16. DOI:10.1016/j.cell.2020.07.024

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione(2648939-40-4)Related Product Information

• Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
• Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
• 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
• Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
• Thalidomide-O-C6-acid
• Thalidomide-4-O-C8-NH2
• Thalidomide-O-C3-acid
• Thalidomide-4-O-C6-NH2 hydrochloride
• Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester
• Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
• Thalidomide-O-C5-acid
• N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Trifluoroacetate
• 6-Bromo-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide