5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Product Name: 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS No.: 2648939-40-4
Chemical Name: 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
Synonyms: Thalidomide-5,6-Cl;1H-Isoindole-1,3(2H)-dione, 5,6-dichloro-2-(2,6-dioxo-3-piperidinyl)-;5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB69724796
Molecular Formula: C13H8Cl2N2O4
Formula Weight: 327.12
MOL File: 2648939-40-4.mol

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5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Property

Boiling point:: 590.1±50.0 °C(Predicted)
Density: 1.672±0.06 g/cm3(Predicted)
pka: 10.52±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Chemical Properties,Usage,Production

Uses

Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.

IC 50

Cereblon

References

[1] Zhang NN, et, al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.e16. DOI:10.1016/j.cell.2020.07.024

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione Suppliers

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2648939-40-4, 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dioneRelated Search:

Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Thalidomide-O-C6-acid Thalidomide-4-O-C8-NH2 Thalidomide-O-C3-acid Thalidomide-4-O-C6-NH2 hydrochloride Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester Thalidomide-O-C5-acid N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Trifluoroacetate 6-Bromo-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Thalidomide-5,6-Cl

1H-Isoindole-1,3(2H)-dione, 5,6-dichloro-2-(2,6-dioxo-3-piperidinyl)-

2648939-40-4