Thalidomide-O-C3-acid

Product Name: Thalidomide-O-C3-acid
CAS No.: 2169266-64-0
Chemical Name: Thalidomide-O-C3-acid
Synonyms: CUN 66640;Thalidomide-O-C3-acid;Thalidomide-4-O-C3-COOH;Thalidomide 4'-ether-alkylC3-acid;4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butanoic acid;4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]butanoic acid;4-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy)butanoic Acid;Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CBNumber: CB68344463
Molecular Formula: C17H16N2O7
Formula Weight: 360.32
MOL File: 2169266-64-0.mol

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Thalidomide-O-C3-acid Property

Boiling point:: 697.4±55.0 °C(Predicted)
Density: 1.502±0.06 g/cm3(Predicted)
pka: 4.56±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 7330
Product name: Thalidomide4'-ether-alkylC3-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $169
Updated: 2021/12/16

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Thalidomide-O-C3-acid Chemical Properties,Usage,Production

Description

CUN 66640, also known as Thalidomide 4'-ether-alkylC3-acid is a cereblon ligand with alkyl linker and terminal acid for onward chemistry. This product has no formal name at the moment.

Uses

Thalidomide-O-C3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024

Thalidomide-O-C3-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-C3-acid Suppliers

China 24 United States 1 Global 25

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7440
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
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ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 14996
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD

Tel: 025-86755008 17751752005
Fax: 025-86755228
Email: hszhang@bestfluorodrug.com
Country: China
ProdList: 2358
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Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengpharma@126.co 18616377689
Email: nanfengpharma@126.com
Country: China
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Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 54995
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View Lastest Price from Thalidomide-O-C3-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-C3-acid 2169266-64-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: >95.00%
Supply Ability: 10g
Release date: 2024-04-01

2169266-64-0, Thalidomide-O-C3-acidRelated Search:

Thalidomide-4-O-C8-NH2 Thalidomide-O-C5-acid Thalidomide-4-O-C6-NH2 hydrochloride Thalidomide-O-C6-acid Thalidomide-O-C10-NH2 Thalidomide-O-C5-NH2 Thalidomide-O-C6-NH2 Thalidomide-linker 9 Thalidomide-linker 6 Thalidomide-O-C6-NH2 TFA Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

Thalidomide 4'-ether-alkylC3-acid

Thalidomide-O-C3-acid

CUN 66640

4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butanoic acid

Thalidomide-4-O-C3-COOH

4-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy)butanoic Acid

4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]butanoic acid

2169266-64-0