Thalidomide-O-C5-acid

Product Name: Thalidomide-O-C5-acid
CAS No.: 2087490-48-8
Chemical Name: Thalidomide-O-C5-acid
Synonyms: PUN 90488;Thalidomide-O-C5-acid;Thalidomide-4-O-C5-COOH;Thalidomide 4'-ether-alkylC5-acid;6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoic acid;6-[2-(2,6-dioxoazaperhydroin-3-yl)-1,3-dioxobenzo[c]azolin-4-yloxy]hexanoic acid;6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexanoic acid;6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic Acid;Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CBNumber: CB88344326
Molecular Formula: C19H20N2O7
Formula Weight: 388.37
MOL File: 2087490-48-8.mol

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Thalidomide-O-C5-acid Property

Boiling point:: 694.4±55.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
pka: 4.73±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 7332
Product name: Thalidomide4'-ether-alkylC5-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $169
Updated: 2021/12/16

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Thalidomide-O-C5-acid Chemical Properties,Usage,Production

Description

PUN 90488, also known as Thalidomide 4'-ether-alkylC5-acid is a cereblon ligand with alkyl linker and terminal acid for onward chemistry. This product has no formal name at the moment.

Uses

Thalidomide-O-C5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024

Thalidomide-O-C5-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-C5-acid Suppliers

China 23 United States 1 Global 24

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
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Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
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Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD

Tel: 025-86755008 17751752005
Fax: 025-86755228
Email: hszhang@bestfluorodrug.com
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Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
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Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
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Shandong Territorial sea Biological Technology Co., LTD

Tel: 15092083467
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Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
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View Lastest Price from Thalidomide-O-C5-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-C5-acid 2087490-48-8
Price: US $0.00/mg
Min. Order: 500mg
Purity: >98.00%
Supply Ability: 500mg
Release date: 2024-04-01

2087490-48-8, Thalidomide-O-C5-acidRelated Search:

Thalidomide-O-C10-NH2 Thalidomide-4-O-C8-NH2 Thalidomide-4-O-C6-NH2 hydrochloride Thalidomide-O-C3-acid Thalidomide-O-C6-acid Thalidomide-O-C5-NH2 Thalidomide-O-C6-NH2 Thalidomide-linker 9 Thalidomide-linker 6 Thalidomide-O-C6-NH2 TFA Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

Thalidomide 4'-ether-alkylC5-acid

Thalidomide-O-C5-acid

6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoic acid

PUN 90488

6-[2-(2,6-dioxoazaperhydroin-3-yl)-1,3-dioxobenzo[c]azolin-4-yloxy]hexanoic acid

Thalidomide-4-O-C5-COOH

6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic Acid

6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexanoic acid

2087490-48-8