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Thalidomide-O-C5-NH2

Product Name
Thalidomide-O-C5-NH2
CAS No.
2307477-23-0
Chemical Name
Thalidomide-O-C5-NH2
Synonyms
Thalidomide-O-C5-NH2;Thalidomide-4-O-C5-NH2;4-((5-aminopentyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-;4-[(5-aminopentyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber
CB49711415
Molecular Formula
C18H21N3O5
Formula Weight
359.38
MOL File
2307477-23-0.mol
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Thalidomide-O-C5-NH2 Property

Boiling point:
624.0±55.0 °C(Predicted)
Density 
1.353±0.06 g/cm3(Predicted)
pka
10.70±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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Thalidomide-O-C5-NH2 Chemical Properties,Usage,Production

Uses

Thalidomide-4-O-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Thalidomide-O-C5-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-C5-NH2 Suppliers

China 5 Global 5
Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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+86-21-50462321
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Jilin Province Woda Biotechnology Co., Ltd.
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13504435624
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1927928688@qq.com
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China
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005
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025-86755228
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hszhang@bestfluorodrug.com
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China
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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13417589054;
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trendseenbio@gmail.com
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China
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9069
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005
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hszhang@bestfluorodrug.com
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China
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2820
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2307477-23-0, Thalidomide-O-C5-NH2Related Search:

Thalidomide-O-C5-acid Thalidomide-O-C6-NH2 Thalidomide-O-C6-NH2 TFA Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-C3-acid Thalidomide-4-O-C8-NH2 Thalidomide-NH-PEG2-C2-NH2 (TFA) 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C10-NH2 1H-Isoindole-1,3(2H)-dione, 5-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propanoic acid

  • Thalidomide-O-C5-NH2
  • 4-((5-aminopentyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
  • Thalidomide-4-O-C5-NH2
  • 4-[(5-aminopentyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2307477-23-0