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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-

Product Name
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-
CAS No.
2509360-22-7
Chemical Name
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-
Synonyms
Thalidomide-4-O-C3-NH2;4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber
CB29310524
Molecular Formula
C16H17N3O5
Formula Weight
331.32
MOL File
2509360-22-7.mol
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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Property

Boiling point:
617.9±55.0 °C(Predicted)
Density 
1.425±0.06 g/cm3(Predicted)
pka
10.70±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties,Usage,Production

Uses

Thalidomide-O-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Suppliers

China 7 Global 7
Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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Jilin Province Woda Biotechnology Co., Ltd.
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13504435624
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1927928688@qq.com
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005
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025-86755228
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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0431-80514535 19917294565
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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13417589054;
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005
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hszhang@bestfluorodrug.com
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China
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Jilin Chinese Academy of Sciences-yanshen Technology
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2509360-22-7, 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-Related Search:

4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-Piperazinepropanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]amino]-4-oxo-Butanoic acid 4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1Hisoindol-5-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, Thalidomide-NH-PEG2-C2-NH2 (TFA) 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C10-NH2 1H-Isoindole-1,3(2H)-dione, 5-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propanoic acid 5-[(3-aminopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C5-NH2 Thalidomide-4-O-C8-NH2

  • 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-
  • 4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • Thalidomide-4-O-C3-NH2
  • 4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • 4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2509360-22-7