Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

Product Name: Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CAS No.: 2169266-67-3
Chemical Name: Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
Synonyms: HUN 66673;Thalidomide-O-C4-COOH;Thalidomide-O-C4-acid;Thalidomide-4-O-C4-COOH;Thalidomide 4'-ether-alkylC4-acid;5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentanoic acid;5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentanoic acid;5-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}pentanoic acid;Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CBNumber: CB58379475
Molecular Formula: C18H18N2O7
Formula Weight: 374.34
MOL File: 2169266-67-3.mol

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Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Property

Boiling point:: 693.8±55.0 °C(Predicted)
Density: 1.460±0.06 g/cm3(Predicted)
pka: 4.66±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 7331
Product name: Thalidomide4'-ether-alkylC4-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $269
Updated: 2021/12/16

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Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Chemical Properties,Usage,Production

Description

HUN 66673, also known as Thalidomide 4'-ether-alkylC4-acid is a cereblon ligand with alkyl linker and terminal acid for onward chemistry. This product has no formal name at the moment.

Uses

Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024

Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Suppliers

China 18 United States 1 Global 19

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
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Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Xi'an Confluore Biological Technology Co., Ltd.

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Jilin Province Woda Biotechnology Co., Ltd.

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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Bide Pharmatech Ltd.

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Beijing Biocreative Technology Co., Ltd.

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TargetMol Chemicals Inc.

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View Lastest Price from Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-C4-acid 2169266-67-3
Price: US $0.00/mg
Min. Order: 500mg
Purity: >95.00%
Supply Ability: 500mg
Release date: 2024-04-01

2169266-67-3, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-Related Search:

Thalidomide-O-C10-NH2 Thalidomide-4-O-C8-NH2 Thalidomide-O-C5-acid Thalidomide-4-O-C6-NH2 hydrochloride Thalidomide-O-C3-acid Thalidomide-O-C6-acid Thalidomide-O-C5-NH2 Thalidomide-O-C6-NH2 Thalidomide-linker 9 Thalidomide-linker 6 Thalidomide-O-C6-NH2 TFA Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

Thalidomide 4'-ether-alkylC4-acid

Thalidomide-O-C4-acid

HUN 66673

5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentanoic acid

Thalidomide-O-C4-COOH

Thalidomide-4-O-C4-COOH

5-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}pentanoic acid

5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentanoic acid

2169266-67-3