Basic information Safety Supplier Related

1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

Basic information Safety Supplier Related

1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Basic information

Product Name:
1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:
  • 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
  • Thalidomide-O-C7-NH2
  • 4-((7-aminoheptyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • Thalidomide-4-O-C7-NH2
  • 4-[(7-Aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS:
2093536-11-7
MF:
C20H25N3O5
MW:
387.43
Mol File:
2093536-11-7.mol
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1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties

Boiling point:
633.9±55.0 °C(Predicted)
Density 
1.298±0.06 g/cm3(Predicted)
pka
10.70±0.40(Predicted)
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1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis

Uses

Thalidomide-4-O-C7-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024

1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-Supplier

Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005
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hszhang@bestfluorodrug.com
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
Tel
025-86755008 17751752005
Email
hszhang@bestfluorodrug.com