SR 3677 dihydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

SR 3677 dihydrochloride Usage And Synthesis

Uses

SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM[1].

IC 50

ROCK-I: 56 nM (IC₅₀); ROCK-II: 3 nM (IC₅₀)

storage

Desiccate at RT

References

[1] Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. DOI:10.1021/jm800986w

SR 3677 dihydrochloride(1781628-88-3)Related Product Information

• SR-95531
• N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide