2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

Appearance

White to off-white Solid

InChI

InChI=1S/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10)

InChIKey

UXXQEVFRPLIOHJ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=CC(C(N)=O)=N1

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

29242990

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Usage And Synthesis

Chemical Properties

Light yellow solid

Uses

2-Chloropyrimidine-4-carboxamide is used as an organic synthesis and pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 2-chloropyrimidine-4-carboxamide from 2-chloropyrimidine-4-carboxylic acid: 2-chloropyrimidine-4-carboxylic acid (500 mg, 1.00 eq.) was dissolved in thionyl chloride (10 mL) and the reaction was heated to 90 °C for 30 min. Upon completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure. The residue was cooled to 0 °C and ammonium hydroxide solution (20 mL) was slowly added. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 320 mg of 2-chloropyrimidine-4-carboxamide as a white solid. The product was analyzed by LC-MS (electrospray ionization, m/z): 158 [M+H]+.

References

[1] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 209

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE(22536-66-9)Related Product Information

• FLONICAMID
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