4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Chemical Properties

Boiling point:

542.3±50.0 °C(Predicted)

Density 

1.367±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Soluble to 100 mM in DMSO and to 100 mM in ethanol

form 

Light beige solid

pka

13.99±0.50(Predicted)

color 

Light yellow to yellow

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Usage And Synthesis

Uses

L- is a potent (Kb = 25 nM), selective antagonist of glucagon.

Definition

ChEBI: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine is a member of pyrroles.

Biological Activity

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC 50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC 50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC 50 > 1 μ M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC 50 = 41 nM), and in murine liver membranes. Orally active in vivo .

storage

Store at RT

4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE(191034-25-0)Related Product Information

• 2,4-Diphenylpyrrole
• 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE