LY 344864
LY 344864 Basic information
- Product Name:
- LY 344864
- Synonyms:
-
- LY 344864
- LY 344864 hydrochloride
- N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride
- (R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide
- (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
- LY344864 HCL
- LY344864;LY-344864
- CS-660
- CAS:
- 186544-26-3
- MF:
- C21H22FN3O
- MW:
- 351.42
- Product Categories:
-
- Inhibitors
- Mol File:
- 186544-26-3.mol
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LY 344864 Chemical Properties
- Boiling point:
- 471.9±45.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO : ≥ 350 mg/mL (995.96 mM)
- pka
- 14.12±0.40(Predicted)
- form
- Powder
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LY 344864 Usage And Synthesis
Uses
LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist.
Biological Activity
Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
LY 344864Supplier
J & K SCIENTIFIC LTD.
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- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
Chengdu NoVi Biotechnology Co., Ltd.
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- 028-81458053
- novibiotech@163.com sales@novi-biotech.com
MedChemexpress LLC
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- 021-58955995
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Credit Asia Chemical Co., Ltd.
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- +86 (21) 61124340