L371,257 Chemical Properties

Boiling point:

728.9±60.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Soluble to 10 mM in DMSO with gentle warming

form 

Powder

pka

0.73±0.20(Predicted)

color 

White to off-white

L371,257 Usage And Synthesis

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

storage

Store at RT

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