lucanthone
lucanthone Basic information
- Product Name:
- lucanthone
- Synonyms:
-
- lucanthone
- 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one
- Lycanthone
- 1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one
- Lucanthonum
- Lucantona
- 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
- Autophagy,inhibit,Lucanthone,Inhibitor
- CAS:
- 479-50-5
- MF:
- C20H24N2OS
- MW:
- 340.48
- EINECS:
- 207-532-4
- Mol File:
- 479-50-5.mol
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lucanthone Chemical Properties
- Melting point:
- 64.5°C
- Boiling point:
- 512.4±50.0 °C(Predicted)
- Density
- 1.0915 (rough estimate)
- refractive index
- 1.5950 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (73.43 mM)
- form
- Solid
- pka
- 10.00±0.25(Predicted)
- color
- Off-white to orange
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lucanthone Usage And Synthesis
Definition
ChEBI: Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a schistosomicide drug, an antineoplastic agent, a photosensitizing agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a prodrug, an adjuvant and a mutagen.
Safety Profile
Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
lucanthoneSupplier
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