Basic information Safety Supplier Related

lucanthone

Basic information Safety Supplier Related

lucanthone Basic information

Product Name:
lucanthone
Synonyms:
  • lucanthone
  • 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one
  • Lycanthone
  • 1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one
  • Lucanthonum
  • Lucantona
  • 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
  • Autophagy,inhibit,Lucanthone,Inhibitor
CAS:
479-50-5
MF:
C20H24N2OS
MW:
340.48
EINECS:
207-532-4
Mol File:
479-50-5.mol
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lucanthone Chemical Properties

Melting point:
64.5°C
Boiling point:
512.4±50.0 °C(Predicted)
Density 
1.0915 (rough estimate)
refractive index 
1.5950 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (73.43 mM)
form 
Solid
pka
10.00±0.25(Predicted)
color 
Off-white to orange
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lucanthone Usage And Synthesis

Definition

ChEBI: Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a schistosomicide drug, an antineoplastic agent, a photosensitizing agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a prodrug, an adjuvant and a mutagen.

Safety Profile

Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

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