Hycanthone Chemical Properties

Melting point:

100.6-102.8°

Boiling point:

570.5±50.0 °C(Predicted)

Density 

1.1269 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO : 30 mg/mL (84.16 mM)

form 

Solid

pka

pKa 3.40 (Uncertain)

color 

Yellow to orange

EPA Substance Registry System

Hycanthone (3105-97-3)

Safety Information

Hazard Codes 

T

Risk Statements 

45-46-20/21/22

Safety Statements 

53-36/37/39-45

WGK Germany 

3

RTECS 

XO1590000

MSDS

• Language:English Provider:SigmaAldrich

Hycanthone Usage And Synthesis

Uses

Antischistosomal.

Uses

Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone (L473700), which is used in the treatment of schistosomiasis.

Definition

ChEBI: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.

General Description

Odorless canary yellow to yellow-orange crystalline powder. Bitter taste.

Air & Water Reactions

1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water.

Reactivity Profile

1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is very sensitive to acid. .

Fire Hazard

Flash point data for 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE are not available; however, 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is probably combustible.

Safety Profile

Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Hycanthone(3105-97-3)Related Product Information

• Sofalcone
• Ceftezole
• Triethyl phosphate
• 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one=2-furancarboxylate
• THIOXANTHENE
• (2-METHYLSULFANYL-PHENYL)-METHANOL
• Thioxanthen-9-one
• 2,6-DIMETHYLTHIOANISOLE
• Hycanthone
• lucanthone
• 2-amino-5-methylbenzophenone