Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Chemical Properties

Melting point:

175 °C(Solv: ethanol (64-17-5))

Boiling point:

626.3±55.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

4°C, away from moisture and light

form 

Solid

pka

13.94±0.70(Predicted)

color 

White to off-white

Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Usage And Synthesis

Uses

Hellebrigenin, one of bufadienolides belonging to cardioactive steroids, is isolated from traditional Chinese medicine Venenum Bufonis. Hellebrigenin induces DNA damage and cell cycle G2/M arrest. Hellebrigenin triggers mitochondria-mediated apoptosis.

References

[1] Deng LJ, et al. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact. 2014 Aug 5;219:184-94. DOI:10.1016/j.cbi.2014.06.003

Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)-(465-90-7)Related Product Information

• 16β-(Acetyloxy)-14,15β-epoxy-3β,5-dihydroxy-19-oxo-5β-bufa-20,22-dienolide
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• 16β-(Acetyloxy)-14,15β-epoxy-3β-hydroxy-19-oxo-5β-bufa-20,22-dienolide
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