etomidoline
etomidoline Basic information
- Product Name:
- etomidoline
- Synonyms:
-
- etomidoline
- 1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
- Amidoline
- K 2680
- Nonspa
- Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI)
- Smedolin
- 2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one
- CAS:
- 21590-92-1
- MF:
- C23H29N3O2
- MW:
- 379.5
- EINECS:
- 2444639
- Mol File:
- 21590-92-1.mol
etomidoline Chemical Properties
- Melting point:
- 106-107°
- Boiling point:
- 507.34°C (rough estimate)
- Density
- 1.1315 (rough estimate)
- refractive index
- 1.6500 (estimate)
- pka
- 8.75±0.10(Predicted)
etomidoline Usage And Synthesis
Originator
Smedolin,Yamanouchi,Japan,1976
Definition
ChEBI: Etomidoline is an organic molecular entity.
Manufacturing Process
31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol)
are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution
5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added
and the resulted mixture is heated at 70°C for 1 hour, and then poured into
an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-
isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to
104°C) is obtained as a byproduct with the above compound. This latter
compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.
Therapeutic Function
Muscle relaxant